| Varieties: | Cardiotonic |
|---|---|
| Component: | Chemical Synthetic Drugs |
| Type: | The First Class |
| Pharmacodynamic Influential Factors: | Animal Species |
| Storage Method: | Moisture Proof |
| Veterinary Reg. No.: | No |
| Samples: |
|---|
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Audited Supplier | Identification | ||
| Name | Pimobendan | |
| Synonyms | 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone | |
| Molecular Structure | ||
| Molecular Formula | C19H18N4O2 | |
| Molecular Weight | 334.37 | |
| CAS Registry Number | 74150-27-9 | |
Pimobendan (INN, or pimobendane; tradenames Vetmedin, Acardi) is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropicand vasodilator effects.
Pimobendan is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also previously known as endocardiosis), or dilated cardiomyopathy.Research has shown that as a monotherapy, pimobendan increases survival time and improves quality of life in canine patients with congestive heart failure secondary to mitral valve disease when compared with benazepril, an ACE inhibitor.[2] However, in clinical practice, it is often used in conjunction with an ACE inhibitor like enalapril or benazepril. Under the trade name Acardi, it is available for human use in Japan.
Pimobendan is a positive inotrope (increases myocardial contractility). It sensitizes and increases the binding efficiency of cardiac troponin in the myofibril to the calcium ions that are already present in systole. In normal hearts it increases the consumption of oxygen and energy to the same degree as dobutamine but in diseased hearts it may not.Pimobendan also causes peripheral vasodilation by inhibiting the function of PDE3. This results in decreased resistance to blood flow through systemic arterioles, which decreases afterload (decreases the failing heart's workload) and reduces the amount of mitral regurgitation.
| Test Items | Standard |
| Appearance | Off white powder |
| Infrared absorption | As per EP |
| Water | ≤ 1.0% |
| Sulphated ash | ≤ 0.1% |
| Related substances | Any other impurities <0.2% |
| HPLC purity | ≥99.50% |
| Heavy metals | ≤ 10ppm |
| Residual Solvents |
Methanol<3000ppm |
| Ethyl acetate<5000ppm | |
| Ethanol<5000ppm | |
| Assay | 98.0%~101.0% |
| Particle size distribution | 25um≥90% |
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